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We mentioned how the basketball random game is played, but in addition to these game conditions, there is a separate kind of challenge for us in each game, some of which are: TYPES OF MAPS AND CHALLENGES AVAILABLE IN THE BASKETBALL RANDOM GAME: in the 2-player option, the cursor does not matter, the characters automatically send the ball to the opposite pot, this prevents mechanical disputes and provides a more comfortable game in the 2-player option. in the 2-person option, one of the players plays the game with the w and the other with the direction keys. The first to score 5 points in a round gets the win. When your character jumps with the ball in his hand, he throws the ball towards wherever your cursor is facing. If you want to throw the ball in your hand into the opposite pot, your cursor (mouse, mouse) comes into play here. As soon as your character's hand touches the ball, the ball is already automatically in their hands. With these movements, you guide your character by jumping along with the upward-facing key from the direction keys on your keyboard. At the beginning of the game, your characters start making back and forth movements to throw the basket ball into the pots in the game. When the game starts in the basket random game, there are 4 characters in total, 2 characters of the opposite side and 2 characters of you. Basketball Random full screen is a game that can be played in full screen. There are options to be able to play with 2 players and 1 game if you choose a 1 if your computer (bot) that we call artificial intelligence 2 player two-player option so you choose goes with you if you have any friend or you can play with your brother on the same keyboard. There are 2 pots in the game, and the person playing the game tries to throw it into the opposite pot. The goal in the game is no different from the basketball we know. The basket random online game is a 2-dimensional (2D) game that can be played on various Internet sites. 5/16/2023 0 Comments Cetus3d print volumeThree different nozzles for different modes of printing. Maximum Build Volume: 7L x 7W x 11HMaximum Heated Bed Temperature: 230 FFilament Diameter: 1.75 mmNozzle diameter: 0.2 mm, 0.4 mm, 0. Upgradable to much more efficient features such as heated bed and auto-calibration.Ĭomponents used in construction are high quality and durable. We would need an enclosure for ABS printing. Cetus 3D Printer MK2 & MK3 Cetus MK2 v/s Cetus MK3 CiteriaĬetus 3D Printer MK2 & MK3 Pros & Cons ProsĮxcellent print output compared to other 3D printers in this category as well as its predecessors. it in its new form very prettily printed, and every way worthy of popular favour. We have got a 0.2 mm Nozzle for fine and sharp detailed printing, a 0.6 mm one for printing big and structural parts, and a 0.4 mm option for the general-purpose printing needs we may come to face. Darton and of an ox, but were four times the size of the Harvey. The Print Quality of Cetus MK3 is really superb due to the Variety of nozzles provided with the printers. Improved Z-axis for better print quality. It features stainless steel HER SHIN linear rails that are quite smooth and enhances the overall accuracy.Ĭetus 3D Printer MK2 & MK3 Printing Quality Changed some sheet metals parts and printed parts to injection molded and CNC machined parts. The Cetus MK3 comes with fantastic precision.Some of the most prominent features of MK3 are : The Cetus MK3 3D Printer comes with some extendable high-end additional features which can be done by oneself or by buying the extended version of MK3. Its technology is based on “Fused Filament Fabrication” (FFF).Ĭetus 3D Printer MK2 & MK3 Features of Cetus MK3 3D Printer 4 Versions (two basic versions and two deluxe versions) are provided for your choice. Inherited classic features from Cetus MK1 & MK2, we make it an upgradable 3D Printer. Specifications Rating: 3.5/5.0 Print Technology: Cetus 3D Printer MK3 is the latest version of Cetus3D Printers. Cetus 3D Printer MK2 & MK3 Key Specifications So keep reading without skipping as skipping a bit might result in missing a lot about Cetus MK3 3D Printer. The company launched a Kickstarter campaign during September. And today we are going to have a review as well as the comparison of the Cetus MK3 3D Printer with its predecessor – Cetus MK2 3D Printer. Cetus3D printer is an FDM-based desktop 3D printer with a build volume of 180 x 180 x 180mm. Whats minimum feature size and what layer thickness should you choose In this comprehensive guide, youll learn how 3D printer resolution affects your 3D. 5/16/2023 0 Comments Accountedge pro 2015 for dummiesI pay at least half our bills online and record the confirmation number in the check number space, which is especially handy for reconciling half a dozen monthly federal and state tax payments to my bank-and to verify that I sent the payments! A great many confirmation numbers (IRS, Colorado payroll, unemployment, credit cards, FedEx, Comcast) exceed the maximum 8 digits allowed for check numbers. I want to retire and sell or hand off the business but can't produce accurate reports via AccountEdge.Īlso I detest the automatic numbering feature for payments (it's great for invoicing) and wish that could be optionally turned off. AccountEdge does not allow me (or my CPA using his copy) to make the year-end adjustment to Retained Earnings reports so we can't know where we stand. As a corporation we carry profits and losses forward as retained earnings and are not required by law to distribute profits as dividends. I find the non-submittable reports work fine for doing the online forms and printing for my files. 941s and W-2s and others but you have to use the numbers to complete the IRS forms online unless you want to buy the reporting program separately. There are payroll reports that accurately calc. New ownership based in Israel may have improved customer service but I can't verify. They didn't charge me, but I had to give employees pay advances and pre-pay bills to completely quit bookkeeping for a week. A recent bug required me to send my entire file (a zipped backup) and take a week off while they repaired it and send back a "FIXED" copy. The live customer support when I first subscribed had a complete lack of understanding of accounting. Their "Knowledge Base" and other support, including videos, is just sad. This is annoying and unavoidable as far as I can tell. There is no option to strip the "pretty" formatting on BalSh or Income reports, so to make them functional you need to remove all that formatting (extra blank lines, merged cells, extra blank columns, multiple font colors, shading). Most of the reports work, but I need to upload many to Excel to manipulate the data (to report retained earnings, for example). Creating custom forms such as checks, invoices, statements is easy I color-code them so customers can easily distinguish an INVOICE (red) from a RECEIPT (green) and so on. The invoicing functions work well, creating and sending pdf invoices via Outlook. They offer no after hours support so you better only have an issue between 9am-5pm eastern time, otherwise you are stuck. There are a few really awesome folks and then again not so much. Especially with how virtual we all have to be nowadays. If it was 10 years ago I could see why this wouldn't be a feature but its 2021 folks and this should be able to be done at this point. There is no way to export data to a banking website for things like Bank of America's positive pay. With that being said they only talk to each other with a manual "sync" each time you want them to update the other. The billing system, if you want to give your customers the ability to be sent their month invoices and make payments, actually resides in another product, Account Edge Connect not in the base Account Edge. There is not mass way to remove and customer/vendor profiles. We recently did an import of our data from the old owners to the new owners and it took the developers some serious time to get that figured our and fixed even after we were told it was not that difficult of a process by support. Accounts receivable and the vendor/customer input needs some serious updating. There are some bigger issues that I am not a fan of with AccountEdge and in my 26 plus years of doing accounting I can say there are some poorer products but there are a lot of much better ones as well. 5/16/2023 0 Comments Wps office 10 reviewWPS Office is slim and cheaper cousin of Microsoft Office-and a good replacement for it. It’s incredibly well priced, bug-free, and allows you to work across multiple devices in multiple places. It is compatible with a massive number of different files, and allows you to share live with others when you’re online, but also still do work on your own when offline. No problem working with MS Office, Corel or Open Office documents. After reading this quick tutorial, you will be able to master how to convert PDF to JPG for free online in WPS office within 4 steps. They have many toolbars at the top, and loads of options in every menu. Thus, it is easier to shuffle between the different files. All 3 programs have the same look and feel with their Microsoft Office 2003 counterparts. It functions how Microsoft Office would, at a fraction of the price. All-in-one app for mail, contacts, and calendar CONS Problems accessing documents through web browsers during testing Automated features in Word produce some unpredictable results Some advanced. Pros: Mine installed easily and worked without any hiccups. All the open documents are contained in a single window in WPS this feature is lacking in Microsoft Office. WPS Office is easy to use, intuitive, and cheap. You download the small file onto your own computer, and have your own personal cloud. It opens common file formats such as WPS, DOC, and DOCX, as well as Microsoft Word template files such as DOT and DOTM. WPS Office was established back in 1989, and there’s few reports of any safety concerns. WPS Office, formerly Kingsoft Office, installs three programs that work as alternatives: Writer, Presentation, and Spreadsheets. While you might be hesitant and wonder if this is just a knock-off of Microsoft Office, there’s nothing to fear. You also get some useful tools like “optimal character recognition” which converts images to word documents or PDFs. It also gives you 20 GB of storage, as well as 9 connected devices. Ratings and Reviews Update: Im happy to say that this version is much more comparable to the Windows version of WPS. This program allows you to convert PDFs into documents, edit PDFs, and merge or split them. Premium allows you to get rid of the adds, as well as access to WPS PDF. Premium costs $29.99 per year (which is about $3.99 per month). Software Full Name: Microsoft Office 2010 Pro Plus October 2020. You can also upgrade to the Premium version of WPS Office for some extra features. See screenshots, read the latest customer reviews, and compare ratings for CueBall Goal. 5/15/2023 0 Comments Encouraging quotes about lifeBut until now retailers have lacked both the technology and the mandate to connect marketing, sales, service, and commerce systems to enable a 360-degree view of the customer. “We’ve been talking about the importance of ‘ customer-centricity’ for some time. After all, companies can leverage data about customers in the moment - what they did in the last 24 minutes or hours, not in the last 24 days.” - Tom Puthiyamadam, transformation consulting leader, PwC I believe consumer experiences need to be far more dynamic than they are today - not just personalized, which we’ve been talking about for a few years. How many consumers follow the same exact path to get to their outcome? Very few. “Customer experience professionals love to think about their customer journey maps, but these can be very rigid. But what they’re doing is making the ones that don’t deliver that kind of great experience all the more obvious.” - Susan Weinschenk, chief behavioral scientist and CEO, The Team W In fact, it’s so easy and seamless that we kind of forget to be impressed. Some companies and products provide such a perfect, seamless experience that it has raised the bar. “Consumers now expect to be able to get things, talk to someone, and do what they want at any time. This means that current sales practices, process, and organizational structure may in fact be hindering their growth more than any external factor they believe they are facing.” – Tiffani Bova, growth and innovation evangelist, Salesforce “ rarely come up for air to re-evaluate how they are selling. “The journey of a thousand miles begins with a single step.” – Lao Tzu, Chinese Taoist philosopher Quotes about business transformation “Many companies get trapped by the paradox of hitting numbers ‘now’ versus improving sales for future quarters or years ahead.” – Tiffani Bova, growth and innovation evangelist, Salesforce Forget everything except what you’re going to do now and do it.” – William Durant, co-founder, General Motors “Employees want to feel inspired by their leaders…hire individuals who will lead by example.” – Jody Kohner, EVP global enablement, Salesforce “I do not know the word ‘quit.’ Either I never did, or I have abolished it.” – Susan Butcher, sled dog racer “If you don’t build your dream, someone else will hire you to help them build theirs.” – Dhirubhai Ambani, founder, Reliance Industries “The only way you are going to have success is to have lots of failures first.” – Sergey Brin, co-founder, Google “Only those who will risk going too far can possibly find out how far one can go.” – T.S. “And the day came when the risk to remain tight in a bud was more painful than the risk it took to blossom.” – Anaïs Nin, writer “The greatest thing in this world is not so much where we stand as in what direction we are moving.” – Johann Wolfgang von Goethe, writer/statesman “Mistakes are the growing pains of wisdom.” – William George Jordan, writer/editor “Everyone wants to live on top of the mountain, but all the happiness and growth occurs while you’re climbing it.” – Andy Rooney, broadcast journalist “Strength and growth come only through continuous effort and struggle.” – Napoleon Hill, author “Conformity is the jailer of freedom and the enemy of growth.” – John F. “Every problem is a gift - without problems we would not grow.” – Tony Robbins, motivational speaker and writer “Motivation is the catalyzing ingredient for every successful innovation.” – Clayton Christensen, economist and Harvard professor “Out of your vulnerabilities will come your strength.” – Sigmund Freud, neurologist and founder of psychoanalysis “Play by the rules, but be ferocious.” – Phil Knight, founder, Nike The journey doesn’t end.” – Michelle Obama, from Becoming I see it instead as forward motion, a means of evolving, a way to reach continuously toward a better self. “Becoming isn’t about arriving somewhere or achieving a certain aim. Have a favorite quote that we missed? Click to tweet and add yours. We’ve rounded up 39 quotes about business growth - and advice for success - to inspire you and spark new ideas. But growth can be difficult, and even the most intrepid among us sometimes need an extra dose of inspiration. Businesses face pressure to grow and evolve rapidly to stay competitive. 5/15/2023 0 Comments Microsoft office emailMore information available on Microsoft's Overview of the Junk Mail Filter support site.Įmails delivered to your Inbox, can also be routed Junk mail folder. The folder is located in the left-hand navigation menu below the Inbox. Sometimes legitimate emails will get routed to this folder. It is important to check your Junk folder periodically. You can turn off that feature by following the Turn Off Focused Inbox instructions. Office 365 automatically filters mail into a "Focused" mailbox or "Other". The departmental mailbox will open in a new window.Type in the name of the departmental mailbox and click Open.Select Open Another Mailbox and a small window will open.Click on your name in the top-right corner of the window and a drop-down menu will appear.Log in to outlook.wm.edu using your own credentials.Set an Auto Reply for a Departmental Mailbox Click Save when finished (bottom right of form).Toggle the Turn on Automatic replies button.Select View all Outlook settings (bottom right in Settings box).Select the gear icon (Settings) in the top right section of the page.How To's Collapsible Table - 10 rows Set an Auto Reply Visit W&M Libraries ( ) and sign in with your student ID.In the Search bar, search for Email/Outlook.Sign into Cornerstone at cornerstone.wm.edu.There are versions for both PC's and Macs. Select videos related to specific Outlook topics on the Outlook Video Training webpage.Ī good starter course is a 48-minute course called Office 365: Learn Outlook, which covers both email and calendar. Or pick-and-choose topics that you are interested in by clicking on the lesson options. Walk through an in-depth training course at your own pace with the Outlook Learning Path (pdf). Microsoft's support site offers an overview of Outlook features with step-by-step instructions on their Outlook Quick Start webpage. View or download the Outlook Quick Start Guide (pdf). Collapsible Table - 5 rows Outlook Quick Start Guide Training for Outlook covers both email and Calendar. Sign in with your W&M email address and you will be directed to the W&M authentication site.ĭuo Two-Factor Authentication is required for Office 365. Microsoft recommends all Apple devices to use Outlook for iOS. Mobile Apps: Many of the Office 365 services have mobile apps available - including email! Find them in your iPhone App Store or Google Play store. Password: Enter your password for your W&M Username.Want to set-up email on your phone? Here's the settings you need: Go to my.wm.edu and click on the Outlook icon.Go to office.wm.edu and click on the Mail tile.You can access your W&M email online several ways. Macs or PCs outside of the leasing program - Contact the Technology Support Center for Outlook installation.PCs on the W&M leasing program - An Outlook client will be installed for you before you receive the computer.Outlook desktop clients are available for both PC's and Macs. Here's what you need to get started with Microsoft Office 365 Email.ĭuo Two-Factor Authentication Get Set-Up Collapsible Table - 5 rows Client Installation In 2017, we transitioned our onsite Exchange servers to Microsoft Office 365, which is a Cloud service. We have relied on Microsoft as a email service since 2010. Let's face it, the world is dependent on email for communication. STUDENT EMAIL - GETTING STARTED WITH O365 Students who have recently transitioned to O365 can find helpful information here: 5/15/2023 0 Comments Thomas raskin drugsFollowing the identification of a crude extract with promising pharmacological activity, the next step is its (often multiple) consecutive bioactivity-guided fractionation until the pure bioactive compounds are isolated. To maximize the diversity of the extracted NPs, the biological material can be subjected to extraction with several solvents of different polarity. The choice of extraction method determines which compound classes will be present in the extract (for example, the use of more polar solvents will result in a higher abundance of polar compounds in the crude extract). The process begins with extraction of NPs from organisms such as bacteria. Steps in the process are shown in purple boxes, with associated key limitations shown in red boxes and advances that are helping to address these limitations in modern natural product (NP)-based drug discovery shown in green boxes. 17), as well as recent developments concerning benefit sharing linked to use of marine genetic resources 18. An additional layer of complexity relates to the regulations defining the need for benefit sharing with countries of origin of the biological material, framed in the United Nations 1992 Convention on Biological Diversity and the Nagoya Protocol, which entered into force in 2014 (ref. Furthermore, gaining intellectual property (IP) rights for (unmodified) NPs exhibiting relevant bioactivities can be a hurdle, since naturally occurring compounds in their original form may not always be patented (legal frameworks vary between countries and are evolving) 16, although simple derivatives can be patent-protected (Box 1). Accessing sufficient biological material to isolate and characterize a bioactive NP may also be challenging 15. Identifying the bioactive compounds of interest can be challenging, and dereplication tools have to be applied to avoid rediscovery of known compounds. 1), which may not be compatible with traditional target-based assays 14. NP screens typically involve a library of extracts from natural sources (Fig. Overall, the NP pool is enriched with ‘bioactive’ compounds covering a wider area of chemical space compared with typical synthetic small-molecule libraries 13.ĭespite these advantages and multiple successful drug discovery examples, several drawbacks of NPs have led pharmaceutical companies to reduce NP-based drug discovery programmes. Furthermore, their use in traditional medicine may provide insights regarding efficacy and safety. NPs are structurally ‘optimized’ by evolution to serve particular biological functions 1, including the regulation of endogenous defence mechanisms and the interaction (often competition) with other organisms, which explains their high relevance for infectious diseases and cancer. The increasing significance of drugs not conforming to this rule is illustrated by the increase in molecular mass of approved oral drugs over the past 20 years 12. Indeed, NPs are a major source of oral drugs ‘beyond Lipinski’s rule of five’ 11. These differences can be advantageous for example, the higher rigidity of NPs can be valuable in drug discovery tackling protein–protein interactions 10. They typically have a higher molecular mass, a larger number of sp 3 carbon atoms and oxygen atoms but fewer nitrogen and halogen atoms, higher numbers of H-bond acceptors and donors, lower calculated octanol–water partition coefficients (cLogP values, indicating higher hydrophilicity) and greater molecular rigidity compared with synthetic compound libraries 1, 6, 7, 8, 9. NPs are characterized by enormous scaffold diversity and structural complexity. NPs offer special features in comparison with conventional synthetic molecules, which confer both advantages and challenges for the drug discovery process. Historically, natural products (NPs) have played a key role in drug discovery, especially for cancer and infectious diseases 1, 2, but also in other therapeutic areas, including cardiovascular diseases (for example, statins) and multiple sclerosis (for example, fingolimod) 3, 4, 5. |